Transcription factor Tlx1 marks a subset of lymphoid tissue organizer-like mesenchymal progenitor cells in the neonatal spleen

Marginal reticular cells: a stromal subset directly descended from the lymphoid tissue organizer

The architecture of secondary lymphoid organs (SLOs) is supported by several non-hematopoietic stromal cells. Currently it is established that two distinct stromal subsets, follicular dendritic cells and fibroblastic reticular cells, play crucial roles in the formation of tissue compartments within SLOs, i.e., the follicle and T zone, respectively. Although stromal cells in the anlagen are esse...

Transcription factor TLX1 controls retinoic acid signaling to ensure spleen development.

The molecular mechanisms that underlie spleen development and congenital asplenia, a condition linked to increased risk of overwhelming infections, remain largely unknown. The transcription factor TLX1 controls cell fate specification and organ expansion during spleen development, and Tlx1 deletion causes asplenia in mice. Deregulation of TLX1 expression has recently been proposed in the pathog...

Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling

Secondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment undergoes profound remodeling to support immune responses. However, chronic inflammatory conditio...

Avian lymphoid leukosis: Virus-like particles in kidney Cells

Assess The Pluripotency of Caprine Umbilical Cord Wharton’s Jelly Mesenchymal Cells By RT-PCR Analysis of Early Transcription Factor Nanog

Objective-  In the present study we investigated the isolation protocol, population doubling time (PDT) and the expression of a pluripotential gene by RT-PCR analysis of early transcription factor Nanog in caprine umbilical cord (CUC) Wharton's jelly mesenchymal cells (WJMCs). Design- Experimental in vitro study.   Animals- Four mix breed goat.   Procedures- CUCs were collected from abattoi...